SCHEMBL6165077

SCHEMBL6165077

CC(C)Cc1nn(-c2ccccn2)c2c1C(=O)CC(C)C2

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCNA2 P20248 8/20 0.45
CDK2 P24941 8/20 0.45
ABCG2 Q9UNQ0 4/20 0.44
CSNK2A2 P19784 3/20 0.44
CSNK2B P67870 3/20 0.44
CSNK2A1 P68400 3/20 0.44
CSNK2A3 Q8NEV1 1/20 0.44
ALDH1A1 P00352 2/20 0.42
MAPT P10636 1/20 0.42
THRB P10828 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
CCNO P22674 1/20 0.38
CCNE1 P24864 1/20 0.38
CCNA1 P78396 1/20 0.38
GABRA1 P14867 2/20 0.37
GABRG2 P18507 2/20 0.37
GABRB3 P28472 2/20 0.37
GABRA5 P31644 2/20 0.37
GABRA3 P34903 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6168301 0.88 SMN1; SMN2 (0.43) CCNA2CDK2ABCG2CSNK2A2CSNK2B
SCHEMBL6166197 0.88 CCNA2 (0.41) CCNA2CDK2ABCG2CSNK2A2CSNK2B
SCHEMBL6165013 0.85 CCNA2 (0.46) CCNA2CDK2ABCG2CSNK2A2CSNK2B
SCHEMBL6167949 0.84 ABCG2 (0.44) CCNA2CDK2ABCG2CSNK2A2CSNK2B
SCHEMBL6163369 0.83 CCNA2 (0.47) CCNA2CDK2ABCG2CSNK2A2CSNK2B
SCHEMBL6165207 0.82 ALDH1A1 (0.46) CCNA2CDK2ABCG2CSNK2A2CSNK2B
SCHEMBL6164944 0.81 CCNA2 (0.62) CCNA2CDK2ABCG2CSNK2A2CSNK2B
SCHEMBL6164726 0.81 CCNA2 (0.47) CCNA2CDK2ABCG2CSNK2A2CSNK2B
SCHEMBL6164703 0.80 OPRM1 (0.45) CCNA2CDK2ALDH1A1MAPTTHRB
SCHEMBL6166364 0.79 CCNA2 (0.39) CCNA2CDK2ABCG2CSNK2A2CSNK2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1177185-B1 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2005-04-20 EP disclosed
US-6716856-B1 CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY PHARMACIA & TUBJOHN SPA (IT) 2004-04-06 US disclosed
EP-1177185-A1 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS PHARMACIA & UPJOHN S.p.A. (IT) 2002-02-06 EP disclosed
WO-2000069846-A1 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS PHARMACIA & UPJOHN S.P.A. (IT) 2000-11-23 WO disclosed