Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.44 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.38 |
| ▸ | BUB1 | O43683 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6770545 | 0.88 | ABCG2 (0.38) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6769517 | 0.88 | SRC (0.39) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6162163 | 0.87 | DHODH (0.41) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6163003 | 0.87 | ABCG2 (0.40) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6771827 | 0.86 | ABCG2 (0.37) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6164477 | 0.84 | ABCG2 (0.43) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6165077 | 0.84 | CCNA2 (0.45) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6164455 | 0.81 | ABCG2 (0.47) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL6165127 | 0.80 | ALDH1A1 (0.43) | ABCG2CSNK2A2CSNK2BCSNK2A1ALDH1A1 | |
| SCHEMBL6167870 | 0.79 | ALDH1A1 (0.49) | ABCG2CSNK2A2CSNK2BCSNK2A1CSNK2A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |