SCHEMBL6165490

SCHEMBL6165490

N#CCCn1nc(-c2cccs2)c2c1CCC2=O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.49
ALDH1A1 P00352 13/20 0.44
MEN1 O00255 12/20 0.44
KMT2A Q03164 12/20 0.44
CYP1A2 P05177 11/20 0.44
CASP1 P29466 10/20 0.44
CASP7 P55210 10/20 0.44
USP2 O75604 10/20 0.44
HSD17B10 Q99714 9/20 0.44
MAPK1 P28482 3/20 0.44
CYP3A4 P08684 9/20 0.41
HIF1A Q16665 5/20 0.41
CLK4 Q9HAZ1 3/20 0.41
GLA P06280 3/20 0.41
MAPT P10636 3/20 0.41
HTT P42858 1/20 0.41
CYP2C9 P11712 6/20 0.40
HPGD P15428 4/20 0.40
BRCA1 P38398 3/20 0.40
TSHR P16473 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6167339 0.84 HTT (0.45) LMNAALDH1A1MEN1KMT2ACASP1
SCHEMBL6167036 0.81 RIPK3 (0.39) ALDH1A1KMT2AMAPTHPGD
SCHEMBL6162649 0.81 PARP1 (0.37) LMNAALDH1A1MEN1KMT2ACYP1A2
SCHEMBL6165983 0.78 ATM (0.44) ALDH1A1KMT2ACYP1A2GLAMAPT
SCHEMBL6166254 0.78 ALDH1A1 (0.38) LMNAALDH1A1MEN1KMT2ACASP1
SCHEMBL6164086 0.77 ALDH1A1 (0.36) ALDH1A1MEN1KMT2ACYP1A2CASP1
SCHEMBL6167558 0.75 BRD4 (0.31)
SCHEMBL6166453 0.74 ALDH1A1 (0.39) ALDH1A1MEN1KMT2ACYP1A2CASP1
SCHEMBL6163581 0.74 CYP1A2 (0.36) LMNAALDH1A1MEN1KMT2ACYP1A2
SCHEMBL6165037 0.72 MAOB (0.42) ALDH1A1MEN1KMT2ACYP1A2CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1177185-B1 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2005-04-20 EP disclosed
US-6716856-B1 CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY PHARMACIA & TUBJOHN SPA (IT) 2004-04-06 US disclosed