Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CCKBR | P32239 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.31 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166822 | 0.84 | HTT (0.44) | ALDH1A1KDM4EHRH3BRD4CREBBP | |
| SCHEMBL6165490 | 0.78 | LMNA (0.49) | TSHRALDH1A1CYP1A2GLAGAA | |
| SCHEMBL6167036 | 0.77 | RIPK3 (0.39) | ALDH1A1BRD4EP300CREBBPMAOB | |
| SCHEMBL6166254 | 0.77 | ALDH1A1 (0.38) | TSHRALDH1A1KDM4EBRD4EP300 | |
| SCHEMBL6167558 | 0.77 | BRD4 (0.31) | BRD4EP300CREBBP | |
| SCHEMBL6164086 | 0.76 | ALDH1A1 (0.36) | ALDH1A1KDM4ECYP1A2GLABRD4 | |
| SCHEMBL6163581 | 0.76 | CYP1A2 (0.36) | TSHRALDH1A1KDM4ECYP1A2GLA | |
| SCHEMBL6165037 | 0.74 | MAOB (0.42) | TSHRALDH1A1CYP1A2GLAMAOB | |
| SCHEMBL6166453 | 0.74 | ALDH1A1 (0.39) | TSHRALDH1A1CYP1A2BRD4EP300 | |
| SCHEMBL6166684 | 0.70 | MAOB (0.33) | TSHRKDM4ECYP1A2GLABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |