Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | EP300 | Q09472 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166254 | 0.81 | ALDH1A1 (0.38) | BRD4EP300CREBBP | |
| SCHEMBL6167036 | 0.80 | RIPK3 (0.39) | BRD4EP300CREBBPPGRNR3C2 | |
| SCHEMBL6165983 | 0.77 | ATM (0.44) | BRD4EP300CREBBP | |
| SCHEMBL6165490 | 0.75 | LMNA (0.49) | — | |
| SCHEMBL6166453 | 0.74 | ALDH1A1 (0.39) | BRD4EP300CREBBP | |
| SCHEMBL6164086 | 0.74 | ALDH1A1 (0.36) | BRD4EP300CREBBP | |
| SCHEMBL6163581 | 0.71 | CYP1A2 (0.36) | — | |
| SCHEMBL6164339 | 0.70 | HTT (0.34) | BRD4EP300CREBBP | |
| SCHEMBL6165037 | 0.69 | MAOB (0.42) | — | |
| SCHEMBL6162649 | 0.68 | PARP1 (0.37) | BRD4EP300CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |