Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.64 |
| ▸ | BCHE | P06276 | 2/20 | 0.61 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11883482 | 0.86 | SIGMAR1 (0.84) | SIGMAR1BCHEMAOACHRM2GAA | |
| SCHEMBL8897410 | 0.84 | LOXL2 (0.61) | BCHEMAOASCN8AOPRM1CA12 | |
| SCHEMBL4065566 | 0.84 | SIGMAR1 (0.88) | SIGMAR1BCHEMAOACHRM2GAA | |
| SCHEMBL6957742 | 0.82 | MAOB (0.61) | SIGMAR1MAOAOPRM1MAPT | |
| Bromide SCHEMBL11691228 | 0.82 | SIGMAR1 (0.84) | SIGMAR1BCHEMAOACHRM2GAA | |
| SCHEMBL580076 | 0.82 | OPRM1 (0.73) | BCHEOPRM1CA12CA1CA2 | |
| SCHEMBL6959119 | 0.81 | TSHR (0.62) | SIGMAR1MAOAMAPT | |
| SCHEMBL6953471 | 0.81 | TSHR (0.62) | SIGMAR1MAOAMAPT | |
| SCHEMBL29912750 | 0.80 | LOXL2 (0.65) | MAOASCN8AOPRM1CA12CA1 | |
| SCHEMBL12626714 | 0.80 | SIGMAR1 (0.58) | SIGMAR1BCHEMAOACHRM2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1210335-B1 | AMINOCARBONYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES, METHOD FOR PRODUCING SAME AND THE USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2005-09-14 | — | — | EP | disclosed |
| US-6512000-B1 | Aminocarbonyl- substituted benzimidazole derivatives for the treatment of diseases in which inhibition of tryptase is of therapeutic such as for treating an inflammatory or allergic disease | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-01-28 | — | — | US | disclosed |
| EP-1210335-A1 | AMINOCARBONYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES, METHOD FOR PRODUCING SAME AND THE USE THEREOF AS MEDICAMENTS | Boehringer Ingelheim Pharma KG (DE) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001014342-A1 | AMINOCARBONYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES, METHOD FOR PRODUCING SAME AND THE USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-01 | — | — | WO | disclosed |