Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 2/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6165665 | 0.85 | ALPL (0.39) | ALPLCRHBPCRHR2ALDH1A1KMT2A | |
| SCHEMBL6164280 | 0.81 | OPRM1 (0.45) | ALDH1A1KMT2ANPSR1OPRM1HSD17B10 | |
| SCHEMBL6166860 | 0.80 | HTT (0.37) | ALDH1A1HTTLMNA | |
| SCHEMBL6771777 | 0.79 | OPRM1 (0.46) | ALDH1A1NPSR1OPRM1LMNAHSP90AB1 | |
| SCHEMBL6168175 | 0.78 | CSNK2A2 (0.33) | — | |
| SCHEMBL6166206 | 0.78 | OPRM1 (0.42) | ALDH1A1KMT2ANPSR1OPRM1LMNA | |
| SCHEMBL6164838 | 0.77 | CCNA2 (0.41) | ALDH1A1KMT2ANPSR1OPRM1LMNA | |
| SCHEMBL6167189 | 0.77 | DHODH (0.31) | — | |
| SCHEMBL6771525 | 0.75 | OPRM1 (0.50) | ALDH1A1NPSR1OPRM1LMNAHSP90AB1 | |
| SCHEMBL6162505 | 0.74 | ALPL (0.67) | ALPLCRHBPCRHR2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |