Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.30 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.30 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6167101 | 0.84 | HTT (0.56) | HTT | |
| SCHEMBL6167293 | 0.83 | HTT (0.42) | HTTCSNK2A1LMNATSHRPLK1 | |
| SCHEMBL6163485 | 0.80 | ALDH1A1 (0.38) | HTTCSNK2A1LMNATSHRALDH1A1 | |
| SCHEMBL6168175 | 0.80 | CSNK2A2 (0.33) | CSNK2A1CSNK2A2CSNK2BABCG2 | |
| SCHEMBL6166030 | 0.80 | ALPL (0.40) | HTTLMNAALDH1A1 | |
| SCHEMBL6167189 | 0.79 | DHODH (0.31) | — | |
| SCHEMBL6766716 | 0.78 | HTT (0.37) | HTTCSNK2A1LMNATSHRALDH1A1 | |
| SCHEMBL6778055 | 0.77 | SRC (0.43) | HTTCSNK2A1LMNATSHRALDH1A1 | |
| SCHEMBL6164396 | 0.77 | ALDH1A1 (0.41) | HTTCSNK2A1LMNATSHRALDH1A1 | |
| SCHEMBL6163994 | 0.76 | HTT (0.39) | HTTLMNATSHRALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |