Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PKN1 | Q16512 | 3/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.43 |
| ▸ | CDC7 | O00311 | 2/20 | 0.43 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.39 |
| ▸ | BUB1 | O43683 | 6/20 | 0.38 |
| ▸ | BRAF | P15056 | 5/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.38 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.38 |
| ▸ | CIT | O14578 | 2/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.38 |
| ▸ | STK10 | O94804 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | RAF1 | P04049 | 2/20 | 0.38 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6164169 | 0.88 | HTT (0.48) | HTTALDH1A1 | |
| SCHEMBL6167036 | 0.83 | RIPK3 (0.39) | PKN1PKN2CDC7RIPK3BUB1 | |
| SCHEMBL6164255 | 0.82 | HTT (0.46) | HTTALDH1A1 | |
| SCHEMBL6167339 | 0.79 | HTT (0.45) | HTTRAF1ALDH1A1 | |
| SCHEMBL6164980 | 0.78 | HTT (0.44) | HTT | |
| SCHEMBL6164796 | 0.76 | HTT (0.43) | HTTRIPK2MAPK1ALDH1A1 | |
| SCHEMBL6161914 | 0.75 | HTT (0.44) | HTTMAPK1ALDH1A1 | |
| SCHEMBL6166822 | 0.75 | HTT (0.44) | HTTALDH1A1 | |
| SCHEMBL6162358 | 0.74 | HTT (0.46) | HTTABL1ALDH1A1 | |
| SCHEMBL6164630 | 0.72 | HTT (0.41) | HTTMAPK10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |