Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6167013 | 0.85 | CCNA2 (0.42) | OPRM1CCNA2CDK2RAB9ASMN1; SMN2 | |
| SCHEMBL6163291 | 0.85 | CCNA2 (0.42) | OPRM1CCNA2CDK2RAB9ASMN1; SMN2 | |
| SCHEMBL6166839 | 0.83 | ALDH1A1 (0.50) | OPRM1CCNA2CDK2RAB9ASMN1; SMN2 | |
| SCHEMBL6165472 | 0.82 | CCNA2 (0.42) | OPRM1CCNA2CDK2RAB9ASMN1; SMN2 | |
| SCHEMBL6166942 | 0.82 | HTT (0.43) | OPRM1CCNA2CDK2RAB9ASMN1; SMN2 | |
| SCHEMBL6166582 | 0.81 | OPRM1 (0.64) | OPRM1CCNA2CDK2HTTKMT2A | |
| SCHEMBL6166892 | 0.81 | CCNA2 (0.53) | OPRM1CCNA2CDK2RAB9ASMN1; SMN2 | |
| SCHEMBL6166211 | 0.78 | CCNA2 (0.50) | OPRM1CCNA2CDK2RAB9ASMN1; SMN2 | |
| SCHEMBL20074683 | 0.77 | OPRM1 (0.55) | OPRM1RAB9ASMN1; SMN2HTTSLC34A1 | |
| SCHEMBL6163994 | 0.77 | HTT (0.39) | OPRM1CCNA2CDK2RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |