Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 18/20 | 0.64 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.61 |
| ▸ | CDK2 | P24941 | 1/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.59 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166153 | 0.84 | CCNA2 (0.47) | OPRM1CCNA2CDK2OPRK1OPRD1 | |
| SCHEMBL6167734 | 0.84 | OPRM1 (0.49) | OPRM1CCNA2CDK2OPRK1OPRD1 | |
| SCHEMBL6165838 | 0.83 | OPRM1 (0.62) | OPRM1CCNA2CDK2OPRK1OPRD1 | |
| SCHEMBL6165095 | 0.82 | ALDH1A1 (0.58) | OPRM1CCNA2CDK2OPRK1OPRD1 | |
| SCHEMBL6162652 | 0.82 | CCNA2 (0.45) | OPRM1CCNA2CDK2OPRK1OPRD1 | |
| SCHEMBL6166409 | 0.81 | OPRM1 (0.56) | OPRM1CCNA2CDK2OPRK1OPRD1 | |
| SCHEMBL6166892 | 0.78 | CCNA2 (0.53) | OPRM1CCNA2CDK2OPRK1OPRD1 | |
| SCHEMBL6164838 | 0.77 | CCNA2 (0.41) | OPRM1CCNA2CDK2OPRK1OPRD1 | |
| SCHEMBL6162861 | 0.76 | OPRM1 (0.65) | OPRM1CCNA2CDK2OPRK1OPRD1 | |
| SCHEMBL6771820 | 0.75 | OPRM1 (0.75) | OPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |