Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 3/20 | 0.53 |
| ▸ | CDK2 | P24941 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.35 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166211 | 0.84 | CCNA2 (0.50) | CCNA2CDK2SMN1; SMN2RAB9AKMT2A | |
| SCHEMBL6164825 | 0.84 | CCNA2 (0.40) | CCNA2CDK2SMN1; SMN2RAB9AKMT2A | |
| SCHEMBL6162980 | 0.84 | CCNA2 (0.40) | CCNA2CDK2SMN1; SMN2RAB9AKMT2A | |
| SCHEMBL6168412 | 0.84 | CCNA2 (0.40) | CCNA2CDK2SMN1; SMN2RAB9AKMT2A | |
| SCHEMBL6167600 | 0.82 | CCNA2 (0.41) | CCNA2CDK2SMN1; SMN2RAB9AKMT2A | |
| SCHEMBL6166364 | 0.82 | CCNA2 (0.39) | CCNA2CDK2SMN1; SMN2RAB9AKMT2A | |
| SCHEMBL6166409 | 0.81 | OPRM1 (0.56) | CCNA2CDK2SMN1; SMN2RAB9AKMT2A | |
| SCHEMBL6166582 | 0.78 | OPRM1 (0.64) | CCNA2CDK2KMT2AOPRM1OPRD1 | |
| SCHEMBL6163506 | 0.77 | CCNA2 (0.35) | CCNA2CDK2SMN1; SMN2RAB9AKMT2A | |
| SCHEMBL6164944 | 0.76 | CCNA2 (0.62) | CCNA2CDK2SMN1; SMN2RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |