Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 7/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.40 |
| ▸ | SLC6A5 | Q9Y345 | 6/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.36 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 5/20 | 0.36 |
| ▸ | UBE2M | P61081 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5941824 | 0.93 | SLC2A1 (0.43) | GPR119CYP3A4SLC2A1REN | |
| SCHEMBL5942077 | 0.92 | GPR119 (0.44) | GPR119SLC6A9KCNH2SLC6A5CYP2D6 | |
| SCHEMBL5941992 | 0.91 | CYP3A4 (0.41) | GPR119CYP3A4SLC2A1REN | |
| SCHEMBL5942462 | 0.90 | REN (0.44) | GPR119SLC6A9KCNH2SLC6A5CYP3A4 | |
| SCHEMBL6168033 | 0.88 | GPR119 (0.40) | GPR119CYP3A4SLC2A1REN | |
| SCHEMBL5941768 | 0.88 | GPR119 (0.39) | GPR119CYP3A4REN | |
| SCHEMBL5942215 | 0.86 | P2RX3 (0.40) | GPR119CYP3A4REN | |
| SCHEMBL5941990 | 0.84 | CYP3A4 (0.45) | CYP3A4REN | |
| SCHEMBL5942419 | 0.84 | SLC2A1 (0.44) | GPR119CYP3A4SLC2A1REN | |
| SCHEMBL5942264 | 0.84 | REN (0.47) | GPR119CYP3A4REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519920-A1 | NOVEL TETRAHYDROPYRIDINE DERIVATIVES AS RENIN INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2005-04-06 | — | — | EP | disclosed |
| WO-2004105738-A2 | USE OF TETRAHYDROPYRIDINE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2004-12-09 | — | — | WO | disclosed |
| WO-2004002957-A1 | NOVEL TETRAHYDROPYRIDINE DERIVATIVES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2004-01-08 | — | — | WO | disclosed |