Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.38 |
| ▸ | SGMS2 | Q8NHU3 | 3/20 | 0.38 |
| ▸ | SGMS1 | Q86VZ5 | 2/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5941824 | 0.94 | SLC2A1 (0.43) | GPR119P2RX3SLC2A1RENCYP3A4 | |
| SCHEMBL5941768 | 0.91 | GPR119 (0.39) | GPR119RENCYP3A4 | |
| SCHEMBL5942247 | 0.91 | GPR119 (0.43) | GPR119P2RX3SGMS2SGMS1SLC2A1 | |
| SCHEMBL5942215 | 0.91 | P2RX3 (0.40) | GPR119P2RX3RENCYP3A4CHRM5 | |
| SCHEMBL5942272 | 0.90 | REN (0.40) | GPR119RENCYP3A4 | |
| SCHEMBL5941992 | 0.89 | CYP3A4 (0.41) | GPR119SLC2A1RENCYP3A4 | |
| SCHEMBL5942462 | 0.88 | REN (0.44) | GPR119RENCYP3A4 | |
| SCHEMBL6166673 | 0.88 | GPR119 (0.41) | GPR119SLC2A1RENCYP3A4 | |
| SCHEMBL5942294 | 0.85 | REN (0.46) | RENCYP3A4 | |
| SCHEMBL5942704 | 0.85 | REN (0.40) | GPR119RENCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519920-A1 | NOVEL TETRAHYDROPYRIDINE DERIVATIVES AS RENIN INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2005-04-06 | — | — | EP | disclosed |
| WO-2004105738-A2 | USE OF TETRAHYDROPYRIDINE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2004-12-09 | — | — | WO | disclosed |
| WO-2004002957-A1 | NOVEL TETRAHYDROPYRIDINE DERIVATIVES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2004-01-08 | — | — | WO | disclosed |