Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 2/20 | 0.59 |
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | HTR1D | P28221 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5827995 | 0.99 | HTR1B (0.58) | HTR1BTAAR1CYP2D6TSHRLMNA | |
| SCHEMBL5827781 | 0.88 | MAOA (0.57) | HTR1BTAAR1CYP2D6TSHRLMNA | |
| SCHEMBL11270249 | 0.78 | NISCH (0.61) | LMNAADRA2AADRA2BADRA2CMAPT | |
| SCHEMBL10918542 | 0.77 | TSHR (0.71) | CYP2D6TSHRLMNACYP1A2MAPT | |
| SCHEMBL5827600 | 0.75 | HTR1B (0.68) | HTR1BTAAR1CYP2D6TSHRLMNA | |
| SCHEMBL14340604 | 0.75 | HTR1B (0.68) | HTR1BTAAR1CYP2D6TSHRLMNA | |
| Tolazoline SCHEMBL34961 | 0.73 | TAAR1 (1.00) | HTR1BTAAR1CYP2D6TSHRLMNA | |
| SCHEMBL5964339 | 0.73 | POLB (0.67) | TSHRLMNAMAPTCYP19A1 | |
| SCHEMBL12643294 | 0.72 | NISCH (0.58) | LMNAADRA2AADRA2BADRA2CMAOB | |
| SCHEMBL29755942 | 0.72 | NISCH (0.58) | LMNAADRA2AADRA2BADRA2CMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1170288-B9 | Diphenylureum derivatives and their use as alpha2/5-HT2c antagonists | SERVIER LAB (FR) | 2005-01-26 | — | — | EP | disclosed |
| EP-1170288-B1 | Diphenylureum derivatives and their use as alpha2/5-HT2c antagonists | SERVIER LAB (FR) | 2004-08-11 | — | — | EP | disclosed |
| EP-1170288-A2 | Diphenylureum derivatives and their use as alpha2/5-HT2c antagonists | LES LABORATOIRES SERVIER (FR) | 2002-01-09 | — | — | EP | disclosed |
| US-6043254-A | ANTIPROLIFERATIVE AGENT; ENZYME INHIBITOR | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-03-28 | — | — | US | disclosed |