Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 4/20 | 0.68 |
| ▸ | TAAR1 | Q96RJ0 | 9/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.65 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.65 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | RAD52 | P43351 | 1/20 | 0.56 |
| ▸ | HTR1D | P28221 | 6/20 | 0.53 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5826973 | 0.86 | MAOA (0.66) | HTR1BTAAR1CYP2D6ADRA2AADRA2B | |
| SCHEMBL14340604 | 0.81 | HTR1B (0.68) | HTR1BTAAR1CYP2D6ADRA2AADRA2B | |
| SCHEMBL953972 | 0.80 | RAD52 (0.82) | HTR1BTAAR1CYP2D6ADRA2AADRA2B | |
| Tolazoline SCHEMBL34961 | 0.79 | TAAR1 (1.00) | HTR1BTAAR1CYP2D6ADRA2AADRA2B | |
| SCHEMBL11130145 | 0.78 | NISCH (0.68) | HTR1BTAAR1CYP2D6ADRA2AADRA2B | |
| Tolazoline SCHEMBL5053858 | 0.78 | TAAR1 (1.00) | HTR1BTAAR1CYP2D6ADRA2AADRA2B | |
| Tolazoline SCHEMBL28254903 | 0.78 | TAAR1 (0.96) | HTR1BTAAR1CYP2D6ADRA2AADRA2B | |
| Tolazoline SCHEMBL34869 | 0.78 | TAAR1 (1.00) | HTR1BTAAR1CYP2D6ADRA2AADRA2B | |
| Tolazoline SCHEMBL9614505 | 0.78 | TAAR1 (1.00) | HTR1BTAAR1CYP2D6ADRA2AADRA2B | |
| SCHEMBL953586 | 0.77 | HTR1B (0.62) | HTR1BTAAR1CYP2D6ADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7026357-B2 | Diphenylurea compounds | LES LABORATOIRES SERVIER (FR) | 2006-04-11 | — | — | US | disclosed |
| EP-1170288-B9 | Diphenylureum derivatives and their use as alpha2/5-HT2c antagonists | SERVIER LAB (FR) | 2005-01-26 | — | — | EP | disclosed |
| US-20040224993-A1 | Diphenylurea compounds | LAVIELLE GILBERT (FR) | 2004-11-11 | — | — | US | disclosed |
| US-6784183-B2 | ANTISEROTONINE AGENTS | LES LABORATOIRES SERVIER (FR) | 2004-08-31 | — | — | US | disclosed |
| EP-1170288-B1 | Diphenylureum derivatives and their use as alpha2/5-HT2c antagonists | SERVIER LAB (FR) | 2004-08-11 | — | — | EP | disclosed |
| US-20020025965-A1 | Antiserotonine agents | ADIR ET COMPAGNIE (FR) | 2002-02-28 | — | — | US | disclosed |
| EP-1170288-A2 | Diphenylureum derivatives and their use as alpha2/5-HT2c antagonists | LES LABORATOIRES SERVIER (FR) | 2002-01-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020025965-A1 | Antiserotonine agents | HTR2C, HTR3C, HTR3A | HTR1B 12/4885TAAR1 99/4885CYP2D6 648/4885 |
| US-20040224993-A1 | Diphenylurea compounds | HTR2C, HTR2A, HTR1A | HTR1B 4/4885TAAR1 224/4885CYP2D6 194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.