Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21365729 | 0.87 | POLB (0.64) | POLBKMT2AMEN1RAB9ARXFP1 | |
| SCHEMBL6166972 | 0.86 | MEN1 (0.60) | POLBKMT2AMEN1PTGDR2ALDH1A1 | |
| SCHEMBL7316803 | 0.86 | FKBP1A (0.67) | POLBKMT2AMEN1PTGDR2PKM | |
| SCHEMBL1040183 | 0.86 | KMT2A (0.63) | POLBKMT2AMEN1RAB9ARXFP1 | |
| SCHEMBL10586023 | 0.80 | TSHR (0.78) | POLBKMT2AMEN1RAB9AKDM4E | |
| SCHEMBL21365414 | 0.79 | POLB (0.69) | POLBKMT2AMEN1RAB9ARXFP1 | |
| SCHEMBL791659 | 0.79 | KMT2A (0.71) | POLBKMT2AMEN1RAB9AKDM4E | |
| SCHEMBL5061551 | 0.79 | LMNA (0.56) | POLBKMT2AMEN1PTGDR2KDM4E | |
| SCHEMBL23064630 | 0.79 | SMN1; SMN2 (0.66) | POLBKMT2AMEN1PTGDR2RAB9A | |
| SCHEMBL12169304 | 0.78 | KMT2A (0.69) | POLBKMT2AMEN1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432686-B1 | TETRAHYDROISOCHINOLINES, THEIR PRODUCTION AND THE USE THEREOF AS ANALGESICS | BAYER HEALTHCARE AG (DE) | 2005-06-29 | — | — | EP | disclosed |
| US-20050049240-A1 | Tetrahydroisochinolines, their production and the use thereof as analgesics | BAYER HEALTHCARE AG (DE) | 2005-03-03 | — | — | US | disclosed |
| EP-1432686-A1 | TETRAHYDROISOCHINOLINES, THEIR PRODUCTION AND THE USE THEREOF AS ANALGESICS | Bayer HealthCare AG (DE) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003029221-A1 | TETRAHYDROISOCHINOLINES, THEIR PRODUCTION AND THE USE THEREOF AS ANALGESICS | BAYER HEALTHCARE AG (DE) | 2003-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050049240-A1 | Tetrahydroisochinolines, their production and the use thereof as analgesics | OPRL1, OPRK1, TPMT | POLB 3228/4885KMT2A 2328/4885MEN1 1822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.