Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP3 | P15309 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12296385 | 0.75 | CRHBP (0.43) | ACP3CRHBPCRHR2HSD11B1CNR2 | |
| SCHEMBL8427460 | 0.75 | ACP3 (0.44) | ACP3HSD11B1CNR2P2RX7SMN1; SMN2 | |
| SCHEMBL29580255 | 0.72 | ACP3 (0.47) | ACP3CRHBPCRHR2HSD11B1CNR2 | |
| SCHEMBL2588201 | 0.72 | P2RX7 (0.47) | ACP3CRHBPCRHR2HSD11B1CNR2 | |
| SCHEMBL2986939 | 0.72 | ACP3 (0.47) | ACP3CRHBPCRHR2HSD11B1CNR2 | |
| SCHEMBL2224459 | 0.72 | P2RX7 (0.47) | ACP3CRHBPCRHR2HSD11B1CNR2 | |
| SCHEMBL13168657 | 0.72 | ACP3 (0.47) | ACP3CRHBPCRHR2HSD11B1CNR2 | |
| SCHEMBL1047625 | 0.72 | P2RX7 (0.52) | ACP3CRHBPCRHR2HSD11B1CNR2 | |
| SCHEMBL29907993 | 0.72 | ACP3 (0.47) | ACP3CRHBPCRHR2HSD11B1CNR2 | |
| SCHEMBL343233 | 0.72 | ACP3 (0.47) | ACP3CRHBPCRHR2HSD11B1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534281-A1 | N-SULFONYLPIPERIDINES AS METALLOPROTEINASE INHIBITORS (TACE) | Astrazeneca AB (SE) | 2005-06-01 | — | — | EP | claimed |
| WO-2004006925-A1 | N-SULFONYLPIPERIDINES AS METALLOPROTEINASE INHIBITORS (TACE) | ASTRAZENECA AB (SE) | 2004-01-22 | — | — | WO | claimed |