SCHEMBL6167178

SCHEMBL6167178

COC(=O)c1nc(C(=O)c2cnccn2)cc(Cl)c1Cl

nearest known ligand 0.44

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.44
KMT2A Q03164 6/20 0.42
MEN1 O00255 4/20 0.42
POLB P06746 2/20 0.42
USP2 O75604 1/20 0.41
NPC1 O15118 2/20 0.40
KDM4E B2RXH2 1/20 0.40
GAA P10253 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
MCL1 Q07820 1/20 0.39
CTDSP1 Q9GZU7 1/20 0.39
LMNA P02545 1/20 0.39
MAPT P10636 1/20 0.39
MRGPRX4 Q96LA9 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6896515 0.83 RAB9A (0.35) RAB9AKMT2AMEN1POLBUSP2
SCHEMBL6163002 0.81 S1PR4 (0.37) KDM4EL3MBTL1
SCHEMBL3971796 0.76 NPSR1 (0.44) KDM4EL3MBTL1
SCHEMBL108950 0.72 KDM4E (0.57) RAB9APOLBNPC1KDM4EGAA
SCHEMBL29651938 0.72 KDM4E (0.57) RAB9APOLBNPC1KDM4EGAA
SCHEMBL6163871 0.71 NQO2 (0.49) KDM4EMRGPRX4
SCHEMBL2133062 0.71 NPSR1 (0.48) KDM4EL3MBTL1
Hydrochloric Acid SCHEMBL29070148 0.70 KDM4E (0.55) RAB9APOLBNPC1KDM4EGAA
Hydrochloric Acid SCHEMBL30529579 0.70 KDM4E (0.55) RAB9APOLBNPC1KDM4EGAA
Hydrochloric Acid SCHEMBL27902568 0.70 KDM4E (0.55) RAB9APOLBNPC1KDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1414814-B1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2005-02-02 EP disclosed
US-6784137-B2 SUCH AS 5,6-DICHLOROPYRIDINE-2-CARBOXYLIC ACID-N-OXIDE FOR PREEMERGENCE APPLICATION DOW AGROSCIENCES LLC 2004-08-31 US disclosed
EP-1414814-A1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES Dow Agrosciences LLC (US) 2004-05-06 EP disclosed
US-20030114311-A1 6-Aryl-4-aminopicolinates and their use as herbicides CORTEVA AGRISCIENCE LLC 2003-06-19 US disclosed
WO-2003011853-A1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2003-02-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030114311-A1 6-Aryl-4-aminopicolinates and their use as herbicides AADAC, DDT, AADAT RAB9A 2477/4885KMT2A 344/4885MEN1 4459/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.