SCHEMBL6163871

SCHEMBL6163871

COC(=O)c1cc(Cl)c(Cl)c(Cl)n1

nearest known ligand 0.49

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
NQO2 P16083 7/20 0.49
NOTUM Q6P988 2/20 0.42
MAPK1 P28482 1/20 0.41
ALDH1A1 P00352 2/20 0.40
KDM4E B2RXH2 2/20 0.39
MRGPRX4 Q96LA9 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17440068 0.84 NQO2 (0.48) NQO2NOTUMMAPK1ALDH1A1KDM4E
SCHEMBL1314550 0.82 NQO2 (0.57) NQO2NOTUMMAPK1ALDH1A1KDM4E
SCHEMBL30563792 0.82 NQO2 (0.44) NQO2NOTUMMAPK1ALDH1A1KDM4E
SCHEMBL26235859 0.82 NQO2 (0.44) NQO2NOTUMMAPK1ALDH1A1KDM4E
SCHEMBL28017398 0.81 ABL1 (0.36) NQO2
SCHEMBL11026722 0.81 CA12 (0.43) ALDH1A1KDM4E
SCHEMBL3971796 0.81 NPSR1 (0.44) NQO2NOTUMALDH1A1KDM4ENPSR1
SCHEMBL11028957 0.80 GABRP (0.48) NQO2NOTUMMAPK1ALDH1A1MRGPRX4
SCHEMBL15449703 0.79 ABL1 (0.39) MAPK1ALDH1A1
SCHEMBL2133062 0.78 NPSR1 (0.48) NQO2ALDH1A1KDM4ENPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3790389-B1 4-AMINO-6-(1,3-BENZODIOXOLE)PICOLINATES AND THEIR USE AS HERBICIDES CORTEVA AGRISCIENCE LLC (US) 2024-02-28 EP disclosed
US-11718604-B2 4-amino-6-(1,3-benzodioxole)picolinates and their use as herbicides DOW AGROSCIENCES LLC 2023-08-08 US disclosed
US-11718604-B2 4-amino-6-(1,3-benzodioxole)picolinates and their use as herbicides DOW AGROSCIENCES LLC 2023-08-08 US disclosed
EP-2970185-B1 4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-AMINO-2-(HETEROCYCLIC)PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES CORTEVA AGRISCIENCE LLC (US) 2023-07-12 EP disclosed
EP-3440938-B1 4-AMINO-6-(4-SUBSTITUTED-PHENYL)-PICOLINATES AND THEIR USE AS HERBICIDES CORTEVA AGRISCIENCE LLC (US) 2023-07-12 EP disclosed
EP-3569600-B1 4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-AMINO-2-(HETEROCYCLIC)PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES CORTEVA AGRISCIENCE LLC (US) 2023-06-14 EP disclosed
US-20210230147-A1 4-AMINO-6-(1,3-BENZODIOXOLE)PICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2021-07-29 US disclosed
US-10765114-B2 4-amino-6-(pyridyl and 2-substitutedphenyl)-picolinates and 6-amino-2-(pyridyl and 2-substitutedphenyl)-pyrimidine-4-carboxylates and their use as herbicides DOW AGROSCIENCES LLC (US) 2020-09-08 US disclosed
EP-2970186-B1 4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-AMINO-2-(HETEROCYCLIC) PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2020-06-10 EP disclosed
EP-3640249-A1 4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-AMINO-2-(HETEROCYCLIC)PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES Dow AgroSciences LLC (US) 2020-04-22 EP disclosed
US-20120190549-A1 6-AMINO-2-SUBSTITUTED-5-VINYLSILYLPYRIMIDINE-4-CARBOXYLIC ACIDS AND ESTERS AND 4-AMINO-6-SUBSTITUTED-3-VINYLSILYLPYRIDINE-2-CARBOXYLIC ACIDS AND ESTERS AS HERBICIDES DOW AGROSCIENCES LLC (US) 2012-07-26 US disclosed
US-20120190548-A1 3-ALKENYL-6-HALO-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2012-07-26 US disclosed
US-20120190549-A1 6-AMINO-2-SUBSTITUTED-5-VINYLSILYLPYRIMIDINE-4-CARBOXYLIC ACIDS AND ESTERS AND 4-AMINO-6-SUBSTITUTED-3-VINYLSILYLPYRIDINE-2-CARBOXYLIC ACIDS AND ESTERS AS HERBICIDES DOW AGROSCIENCES LLC (US) 2012-07-26 US disclosed
US-20120190549-A1 6-AMINO-2-SUBSTITUTED-5-VINYLSILYLPYRIMIDINE-4-CARBOXYLIC ACIDS AND ESTERS AND 4-AMINO-6-SUBSTITUTED-3-VINYLSILYLPYRIDINE-2-CARBOXYLIC ACIDS AND ESTERS AS HERBICIDES DOW AGROSCIENCES LLC (US) 2012-07-26 US disclosed
US-20120190548-A1 3-ALKENYL-6-HALO-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2012-07-26 US disclosed
EP-1414814-B1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2005-02-02 EP disclosed
US-6784137-B2 SUCH AS 5,6-DICHLOROPYRIDINE-2-CARBOXYLIC ACID-N-OXIDE FOR PREEMERGENCE APPLICATION DOW AGROSCIENCES LLC 2004-08-31 US disclosed
EP-1414814-A1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES Dow Agrosciences LLC (US) 2004-05-06 EP disclosed
US-20030114311-A1 6-Aryl-4-aminopicolinates and their use as herbicides CORTEVA AGRISCIENCE LLC 2003-06-19 US disclosed
WO-2003011853-A1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2003-02-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10765114-B2 4-amino-6-(pyridyl and 2-substitutedphenyl)-picolinates and 6-amino-2-(pyridyl and 2-substitutedphenyl)-pyrimidine-4-carboxylates and their use as herbicides DDT, P2RX6, PLPBP NQO2 434/4885NOTUM 2085/4885MAPK1 4351/4885
US-11718604-B2 4-amino-6-(1,3-benzodioxole)picolinates and their use as herbicides ABAT, DAO, HPD NQO2 1110/4885NOTUM 1300/4885MAPK1 3251/4885
US-20030114311-A1 6-Aryl-4-aminopicolinates and their use as herbicides AADAC, DDT, AADAT NQO2 995/4885NOTUM 66/4885MAPK1 3812/4885
US-20120190549-A1 6-AMINO-2-SUBSTITUTED-5-VINYLSILYLPYRIMIDINE-4-CARBOXYLIC ACIDS AND ESTERS AND 4-AMINO-6-SUBSTITUTED-3-VINYLSILYLPYRIDINE-2-CARBOXYLIC ACIDS AND ESTERS AS HERBICIDES DDT, PFAS, WEE2 NQO2 2475/4885NOTUM 14/4885MAPK1 4441/4885
US-20210230147-A1 4-AMINO-6-(1,3-BENZODIOXOLE)PICOLINATES AND THEIR USE AS HERBICIDES ABAT, DAO, HPD NQO2 1110/4885NOTUM 1300/4885MAPK1 3251/4885
US-20120190548-A1 3-ALKENYL-6-HALO-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES ATL3, AAAS, HDHD5 NQO2 2006/4885NOTUM 48/4885MAPK1 4514/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.