Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | IDE | P14735 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1172184 | 0.92 | KMO (0.55) | KMOMAPTAKR1C3ALDH1A1LMNA | |
| SCHEMBL6167415 | 0.88 | NPC1 (0.46) | MAPTAKR1C3ALDH1A1LMNAKDM4E | |
| SCHEMBL2724092 | 0.87 | KMO (0.60) | KMOMAPTAKR1C3ALDH1A1LMNA | |
| SCHEMBL17542589 | 0.86 | MAPT (0.48) | MAPTAKR1C3ALDH1A1IDEPKM | |
| Morpholine SCHEMBL6167416 | 0.84 | MAPT (0.46) | KMOMAPTALDH1A1LMNAPAX8 | |
| SCHEMBL1172381 | 0.83 | SMN1; SMN2 (0.57) | MAPTAKR1C3ALDH1A1LMNAKDM4E | |
| SCHEMBL5129188 | 0.81 | MAPT (0.50) | MAPTAKR1C3ALDH1A1LMNAKDM4E | |
| SCHEMBL14434287 | 0.80 | KMO (0.56) | KMOMAPTAKR1C3ALDH1A1LMNA | |
| SCHEMBL1172369 | 0.78 | MAPT (0.54) | MAPTAKR1C3ALDH1A1KDM4EIDE | |
| SCHEMBL2712653 | 0.78 | MAPT (0.54) | MAPTAKR1C3ALDH1A1KDM4EIDE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509499-A1 | PYRROLE COMPOUNDS FOR THE TREATMENT OF PROSTAGLANDIN MEDIATED DISEASES | GLAXO GROUP LIMITED (GB) | 2005-03-02 | — | — | EP | disclosed |
| WO-2003101959-A1 | PYRROLE COMPOUNDS FOR THE TREATMENT OF PROSTAGLANDIN MEDIATED DISEASES | GLAXO GROUP LIMITED (GB) | 2003-12-11 | — | — | WO | disclosed |