Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6167412 | 0.84 | KMO (0.48) | MAPTALDH1A1CYP2C9LMNAKMO | |
| SCHEMBL6167415 | 0.80 | NPC1 (0.46) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL1172184 | 0.78 | KMO (0.55) | MAPTALDH1A1KMT2ATDP1LMNA | |
| SCHEMBL2724092 | 0.75 | KMO (0.60) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL17542589 | 0.71 | MAPT (0.48) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL2710964 | 0.71 | LMNA (0.57) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL1172381 | 0.70 | SMN1; SMN2 (0.57) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL1172309 | 0.69 | NPC1 (0.56) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL2712184 | 0.68 | MRGPRX4 (0.49) | MAPTALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL5129188 | 0.67 | MAPT (0.50) | MAPTALDH1A1NPC1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509499-A1 | PYRROLE COMPOUNDS FOR THE TREATMENT OF PROSTAGLANDIN MEDIATED DISEASES | GLAXO GROUP LIMITED (GB) | 2005-03-02 | — | — | EP | disclosed |
| WO-2003101959-A1 | PYRROLE COMPOUNDS FOR THE TREATMENT OF PROSTAGLANDIN MEDIATED DISEASES | GLAXO GROUP LIMITED (GB) | 2003-12-11 | — | — | WO | disclosed |