Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | IDE | P14735 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.46 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1172184 | 0.87 | KMO (0.55) | MAPTAKR1C3KDM4EGLAPKM | |
| SCHEMBL1172381 | 0.86 | SMN1; SMN2 (0.57) | MAPTAKR1C3KDM4EPKMGAA | |
| SCHEMBL2712653 | 0.83 | MAPT (0.54) | MAPTAKR1C3KDM4EPKMALDH1A1 | |
| SCHEMBL1172369 | 0.83 | MAPT (0.54) | MAPTAKR1C3KDM4EPKMALDH1A1 | |
| SCHEMBL2712582 | 0.83 | MAPT (0.47) | MAPTAKR1C3KDM4EPKMGAA | |
| SCHEMBL1926767 | 0.83 | MAPT (0.53) | MAPTAKR1C3KDM4EGLAGAA | |
| SCHEMBL2710964 | 0.83 | LMNA (0.57) | MAPTAKR1C3GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL2712073 | 0.81 | SLC6A9 (0.50) | MAPTAKR1C3KDM4EPKMALDH1A1 | |
| SCHEMBL6167412 | 0.81 | KMO (0.48) | MAPTAKR1C3KDM4EGLAPKM | |
| Formaldehyde SCHEMBL19406154 | 0.81 | MAPT (0.51) | MAPTAKR1C3PKMALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242663-A1 | NOVEL PYRIMIDINE DERIVATIVES 698 | ASTRAZENECA AB (SE) | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242663-A1 | NOVEL PYRIMIDINE DERIVATIVES 698 | EPHB4, EPHB1, NME2 | MAPT 3593/4885AKR1C3 1583/4885KDM4E 1632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.