Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | IDE | P14735 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6167412 | 0.88 | KMO (0.48) | MAPTALDH1A1AKR1C3KDM4ELMNA | |
| SCHEMBL17542589 | 0.84 | MAPT (0.48) | POLBMAPTALDH1A1AKR1C3MEN1 | |
| SCHEMBL2710964 | 0.83 | LMNA (0.57) | NPC1POLBMAPTALDH1A1AKR1C3 | |
| SCHEMBL1172381 | 0.81 | SMN1; SMN2 (0.57) | MAPTALDH1A1AKR1C3MEN1KMT2A | |
| Morpholine SCHEMBL6167416 | 0.80 | MAPT (0.46) | NPC1POLBMAPTALDH1A1MEN1 | |
| SCHEMBL1172309 | 0.80 | NPC1 (0.56) | NPC1POLBMAPTALDH1A1MEN1 | |
| SCHEMBL1172184 | 0.80 | KMO (0.55) | MAPTALDH1A1AKR1C3KMT2AKDM4E | |
| SCHEMBL5129188 | 0.79 | MAPT (0.50) | NPC1MAPTALDH1A1AKR1C3KDM4E | |
| SCHEMBL2712184 | 0.77 | MRGPRX4 (0.49) | NPC1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1172369 | 0.76 | MAPT (0.54) | POLBMAPTALDH1A1AKR1C3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509499-A1 | PYRROLE COMPOUNDS FOR THE TREATMENT OF PROSTAGLANDIN MEDIATED DISEASES | GLAXO GROUP LIMITED (GB) | 2005-03-02 | — | — | EP | disclosed |
| WO-2003101959-A1 | PYRROLE COMPOUNDS FOR THE TREATMENT OF PROSTAGLANDIN MEDIATED DISEASES | GLAXO GROUP LIMITED (GB) | 2003-12-11 | — | — | WO | disclosed |