Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 10/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166809 | 0.77 | EGFR (0.55) | MEN1KMT2AALDH1A1TDP1EGFR | |
| SCHEMBL6167611 | 0.75 | NAMPT (0.46) | MEN1KMT2AALDH1A1EGFRSRC | |
| SCHEMBL18157727 | 0.74 | CYP11B1 (0.53) | MEN1KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL5960508 | 0.73 | EGFR (0.56) | MEN1KMT2AALDH1A1TDP1EGFR | |
| SCHEMBL20223300 | 0.72 | CYP11B1 (0.58) | MEN1KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL20225455 | 0.70 | CYP11B1 (0.51) | MEN1KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL4189420 | 0.70 | EGFR (0.56) | MEN1KMT2AALDH1A1TDP1EGFR | |
| SCHEMBL9051693 | 0.69 | EGFR (0.66) | MEN1KMT2AALDH1A1TDP1EGFR | |
| SCHEMBL6888612 | 0.69 | CYP11B1 (0.70) | MEN1KMT2AALDH1A1TDP1MAPT | |
| SCHEMBL6166793 | 0.68 | KDM4E (0.63) | MEN1KMT2AALDH1A1TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1495016-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS MODULATORS OF P38 MAP KINASE | Astex Technology Limited (GB) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003087087-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS MODULATORS OF P38 MAP KINASE | ASTEX TECHNOLOGY LIMITED (GB) | 2003-10-23 | — | — | WO | disclosed |