Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | FNTA | P49354 | 3/20 | 0.43 |
| ▸ | FNTB | P49356 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4231056 | 0.75 | EGFR (0.46) | ALDH1A1EGFRSRCCNR1 | |
| SCHEMBL6167845 | 0.75 | MEN1 (0.44) | NAMPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL4189420 | 0.69 | EGFR (0.56) | ALDH1A1KDM4EMEN1KMT2AEGFR | |
| SCHEMBL5960508 | 0.69 | EGFR (0.56) | ALDH1A1MEN1KMT2AEGFRSRC | |
| SCHEMBL6166809 | 0.68 | EGFR (0.55) | ALDH1A1KDM4EMEN1KMT2AEGFR | |
| SCHEMBL9051693 | 0.68 | EGFR (0.66) | ALDH1A1KDM4EMEN1KMT2AEGFR | |
| SCHEMBL10806849 | 0.68 | ATM (0.54) | ALDH1A1KDM4EMEN1KMT2APOLB | |
| SCHEMBL6888085 | 0.68 | ALDH1A1 (0.59) | ALDH1A1 | |
| SCHEMBL6167610 | 0.67 | HTR6 (0.65) | KDM4E | |
| SCHEMBL7515319 | 0.66 | EGFR (0.52) | ALDH1A1KDM4EMEN1KMT2AEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1495016-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS MODULATORS OF P38 MAP KINASE | Astex Technology Limited (GB) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003087087-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS MODULATORS OF P38 MAP KINASE | ASTEX TECHNOLOGY LIMITED (GB) | 2003-10-23 | — | — | WO | disclosed |