Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 6/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169729 | 0.82 | LMNA (0.38) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6169257 | 0.80 | RXFP1 (0.50) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6167002 | 0.79 | SMN1; SMN2 (0.40) | MAPTPTGS2KDM4EALDH1A1 | |
| SCHEMBL6169278 | 0.77 | LMNA (0.42) | PTGS2KMT2AALDH1A1 | |
| SCHEMBL1027461 | 0.77 | SMN1; SMN2 (0.43) | AKR1B1MAPTPTGS1PTGS2PDE3A | |
| SCHEMBL30314714 | 0.77 | MEN1 (0.38) | MAPTPTGS1PTGS2MEN1CYP1A2 | |
| SCHEMBL6170078 | 0.76 | KMT2A (0.42) | MAPTMEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL17438051 | 0.76 | PTPN1 (0.42) | PTPN1MAPTSLC22A12MEN1KMT2A | |
| SCHEMBL3524883 | 0.72 | MAPT (0.56) | AKR1B1MAPTMEN1CYP1A2CYP2C9 | |
| SCHEMBL11203269 | 0.72 | ALDH1A1 (0.49) | AKR1B1MAPTMEN1CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531812-A1 | FUSED HETEROARYL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS IN THE TREATMENT OF I.A. RHEUMATOID ARTHRISTIS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004010995-A1 | FUSED HETEROARYL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS IN THE TREATMENT OF I.A. RHEUMATOID ARTHRISTIS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-02-05 | — | — | WO | disclosed |