Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169278 | 0.93 | LMNA (0.42) | SMN1; SMN2LMNARXFP1PTGS2NPC1 | |
| SCHEMBL6169257 | 0.86 | RXFP1 (0.50) | SMN1; SMN2LMNARXFP1NPC1RAB9A | |
| SCHEMBL6169729 | 0.83 | LMNA (0.38) | SMN1; SMN2LMNAMAPTRXFP1NPC1 | |
| SCHEMBL6170078 | 0.81 | KMT2A (0.42) | LMNAMAPTRXFP1NPC1RAB9A | |
| SCHEMBL6167929 | 0.79 | AURKA (0.39) | MAPTPTGS2ALDH1A1KDM4E | |
| SCHEMBL3522105 | 0.77 | RAB9A (0.44) | SMN1; SMN2LMNAMAPTNPC1RAB9A | |
| SCHEMBL3525870 | 0.70 | RAB9A (0.43) | SMN1; SMN2LMNAMAPTNPC1RAB9A | |
| SCHEMBL30314714 | 0.70 | MEN1 (0.38) | SMN1; SMN2MAPTRXFP1PTGS2NPC1 | |
| SCHEMBL6169856 | 0.68 | RAB9A (0.53) | SMN1; SMN2LMNAMAPTNPC1RAB9A | |
| SCHEMBL17438051 | 0.65 | PTPN1 (0.42) | SMN1; SMN2MAPTRXFP1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531812-A1 | FUSED HETEROARYL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS IN THE TREATMENT OF I.A. RHEUMATOID ARTHRISTIS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004010995-A1 | FUSED HETEROARYL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS IN THE TREATMENT OF I.A. RHEUMATOID ARTHRISTIS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-02-05 | — | — | WO | disclosed |