Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 5/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169257 | 0.86 | RXFP1 (0.50) | LMNARXFP1GSK3BSMN1; SMN2L3MBTL1 | |
| SCHEMBL6167002 | 0.83 | SMN1; SMN2 (0.40) | LMNARXFP1SMN1; SMN2L3MBTL1RAB9A | |
| SCHEMBL6167929 | 0.82 | AURKA (0.39) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL6169278 | 0.81 | LMNA (0.42) | LMNARXFP1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6170078 | 0.80 | KMT2A (0.42) | LMNARXFP1GSK3BRAB9ANPC1 | |
| SCHEMBL30314714 | 0.76 | MEN1 (0.38) | RXFP1SMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL6168162 | 0.75 | RXFP1 (0.40) | LMNARXFP1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL3523616 | 0.75 | LMNA (0.47) | LMNASMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL17454396 | 0.70 | ALDH1A1 (0.40) | SMN1; SMN2L3MBTL1RAB9AALDH1A1MAPT | |
| SCHEMBL6171513 | 0.70 | BACE1 (0.41) | HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531812-A1 | FUSED HETEROARYL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS IN THE TREATMENT OF I.A. RHEUMATOID ARTHRISTIS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004010995-A1 | FUSED HETEROARYL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS IN THE TREATMENT OF I.A. RHEUMATOID ARTHRISTIS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-02-05 | — | — | WO | disclosed |