Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | DBH | P09172 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168325 | 0.85 | MAPT (0.50) | MAPK14THRBALDH1A1SMN1; SMN2PSMB1 | |
| SCHEMBL13392342 | 0.85 | PSMB1 (0.48) | MAPK14ALDH1A1MEN1KMT2APSMB1 | |
| SCHEMBL31241086 | 0.85 | PSMB1 (0.48) | MAPK14ALDH1A1MEN1KMT2APSMB1 | |
| SCHEMBL6171027 | 0.85 | EGLN1 (0.53) | POLBTHRBALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL6169682 | 0.84 | MAPT (0.55) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL6168739 | 0.83 | FGFR1 (0.48) | MAPK14THRBALDH1A1SMN1; SMN2PSMB1 | |
| SCHEMBL6178075 | 0.81 | PIK3R1 (0.46) | ALDH1A1KDM4EMEN1KMT2APSMB1 | |
| SCHEMBL16044140 | 0.81 | FGFR1 (0.51) | MAPK14ALDH1A1SMN1; SMN2DBHCYP11B1 | |
| SCHEMBL2611281 | 0.81 | EPHX2 (0.48) | MAPK14ALDH1A1KDM4EL3MBTL1HDAC3 | |
| SCHEMBL6190398 | 0.80 | PSMB1 (0.46) | ALDH1A1PSMB1PSMB5DBHHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1530472-A1 | ISOQUINOLINE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2005-05-18 | — | — | EP | disclosed |
| US-20040044000-A1 | Isoquinoline derivatives as matrix metalloproteinase inhibitors | BUNKER AMY MAE (US) | 2004-03-04 | — | — | US | disclosed |
| WO-2004014379-A1 | ISOQUINOLINE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044000-A1 | Isoquinoline derivatives as matrix metalloproteinase inhibitors | MMP1, MMP13, MMP9 | MAPK14 576/4885POLB 672/4885THRB 4378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.