Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.45 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 3/20 | 0.44 |
| ▸ | PPARA | Q07869 | 3/20 | 0.44 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.42 |
| ▸ | BID | P55957 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171376 | 0.84 | HDAC3 (0.54) | MAPTALDH1A1LMNANOD2NOD1 | |
| SCHEMBL6170232 | 0.81 | FLT1 (0.50) | MAPTALDH1A1LMNANOD2NOD1 | |
| SCHEMBL6172885 | 0.81 | ALDH1A1 (0.49) | MAPTALDH1A1LMNANOD2NOD1 | |
| SCHEMBL6172493 | 0.80 | NOD2 (0.50) | MAPTALDH1A1LMNANOD2NOD1 | |
| SCHEMBL6170479 | 0.80 | HDAC3 (0.52) | MAPTALDH1A1LMNANOD2NOD1 | |
| SCHEMBL6171127 | 0.79 | HDAC3 (0.49) | MAPTALDH1A1LMNANOD2NOD1 | |
| SCHEMBL6171807 | 0.79 | MAPT (0.47) | MAPTALDH1A1LMNANOD2NOD1 | |
| SCHEMBL6170056 | 0.78 | HDAC3 (0.50) | MAPTALDH1A1LMNANOD2NOD1 | |
| SCHEMBL27574940 | 0.76 | HDAC3 (0.48) | MAPTALDH1A1LMNANOD2NOD1 | |
| SCHEMBL427119 | 0.75 | TUBB4A (0.53) | MAPTALDH1A1LMNANOD2NOD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |