Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 6/20 | 0.50 |
| ▸ | FLT4 | P35916 | 6/20 | 0.50 |
| ▸ | KDR | P35968 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CCR2 | P41597 | 1/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.47 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 3/20 | 0.46 |
| ▸ | PPARA | Q07869 | 3/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | BID | P55957 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172885 | 0.93 | ALDH1A1 (0.49) | FLT1FLT4KDRALDH1A1LMNA | |
| SCHEMBL6171376 | 0.86 | HDAC3 (0.54) | ALDH1A1LMNAMAPTCCR2NOD2 | |
| SCHEMBL6172493 | 0.86 | NOD2 (0.50) | FLT1FLT4KDRALDH1A1LMNA | |
| SCHEMBL6168047 | 0.81 | MAPT (0.47) | ALDH1A1LMNAMAPTCCR2NOD2 | |
| SCHEMBL6170479 | 0.81 | HDAC3 (0.52) | ALDH1A1LMNAMAPTCCR2NOD2 | |
| SCHEMBL6171807 | 0.81 | MAPT (0.47) | ALDH1A1LMNAMAPTCCR2NOD2 | |
| SCHEMBL9623459 | 0.80 | CCR2 (0.53) | FLT1FLT4KDRALDH1A1LMNA | |
| SCHEMBL6170056 | 0.80 | HDAC3 (0.50) | ALDH1A1LMNAMAPTCCR2NOD2 | |
| SCHEMBL6171127 | 0.79 | HDAC3 (0.49) | ALDH1A1LMNAMAPTCCR2NOD2 | |
| SCHEMBL17556133 | 0.78 | RECQL (0.50) | FLT1FLT4KDRALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |