Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 3/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5627949 | 0.92 | MRGPRX4 (0.48) | CCR5MRGPRX4MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL5631282 | 0.85 | TUBB1 (0.51) | CCR5MRGPRX4ALDH1A1KDM4EMAPT | |
| SCHEMBL5629610 | 0.84 | MAOA (0.53) | MRGPRX4MTNR1AMTNR1BALDH1A1KDM4E | |
| SCHEMBL6166950 | 0.81 | ERN1 (0.52) | CCR5MRGPRX4ALDH1A1KDM4EMAPT | |
| SCHEMBL5474984 | 0.80 | CCR5 (0.53) | CCR5MRGPRX4MAOAMAOB | |
| SCHEMBL5465872 | 0.79 | PTGER1 (0.57) | CCR5MRGPRX4KMT2A | |
| SCHEMBL5629550 | 0.79 | LRRK2 (0.55) | CCR5MTNR1AMTNR1BPOLBHDAC8 | |
| SCHEMBL17770539 | 0.77 | MRGPRX4 (0.67) | CCR5MRGPRX4KDM4EMAPTKMT2A | |
| SCHEMBL5627428 | 0.76 | MAOB (0.47) | MRGPRX4MTNR1AMTNR1BMAOB | |
| SCHEMBL5629957 | 0.76 | MTNR1A (0.45) | MTNR1AMTNR1BKMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509499-A1 | PYRROLE COMPOUNDS FOR THE TREATMENT OF PROSTAGLANDIN MEDIATED DISEASES | GLAXO GROUP LIMITED (GB) | 2005-03-02 | — | — | EP | disclosed |
| WO-2003101959-A1 | PYRROLE COMPOUNDS FOR THE TREATMENT OF PROSTAGLANDIN MEDIATED DISEASES | GLAXO GROUP LIMITED (GB) | 2003-12-11 | — | — | WO | disclosed |