Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.50 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.50 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29206326 | 0.82 | BRD4 (0.64) | DAOHSD17B10KDM4EHPGDALDH1A1 | |
| SCHEMBL2008746 | 0.81 | KDR (0.68) | DAOHSD17B10KDM4EHPGDALDH1A1 | |
| SCHEMBL29712353 | 0.81 | KDR (0.68) | DAOHSD17B10KDM4EHPGDALDH1A1 | |
| SCHEMBL30875870 | 0.81 | CYP19A1 (0.61) | HSD17B10MAOBHPGDALDH1A1MAPT | |
| SCHEMBL17505156 | 0.81 | NPC1 (0.51) | HSD17B10KDM4EHPGDALDH1A1MAPT | |
| SCHEMBL10980382 | 0.81 | KMT2A (0.61) | DAOHSD17B10KDM4EALDH1A1MAPT | |
| SCHEMBL9270293 | 0.81 | SMAD3 (0.50) | DAOHPGDALDH1A1MAPTCTDSP1 | |
| SCHEMBL29206329 | 0.81 | CYP19A1 (0.61) | HSD17B10MAOBHPGDALDH1A1MAPT | |
| SCHEMBL7196311 | 0.80 | ALDH1A1 (0.70) | HSD17B10KDM4EHPGDALDH1A1MAPT | |
| SCHEMBL27255974 | 0.77 | KDM4E (0.57) | HSD17B10KDM4EHPGDALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097138-B1 | PHARMACEUTICAL COMPOSITIONS COMPRISING 2-QUINOLONES | LAFON LABOR (FR) | 2005-12-07 | — | — | EP | disclosed |
| CN-1195740-C | Pharmaceutical composition containing 2-quinolinone | LAFON LABOR (FR) | 2005-04-06 | — | — | CN | disclosed |
| US-6593342-B1 | Activity on the proliferation of clonogenic cells in tumours and comprising an efficient amount of a compound selected among the compounds | LABORATOIRE L. LAFON (FR) | 2003-07-15 | — | — | US | disclosed |
| CN-1309639-A | Pharmaceutical composition containing 2-quinolinone | LAFON LABOR (FR) | 2001-08-22 | — | — | CN | disclosed |
| EP-1097138-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING 2-QUINOLONES | LABORATOIRE L. LAFON (FR) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000003990-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING 2-QUINOLONES | LABORATOIRE L. LAFON (FR) | 2000-01-27 | — | — | WO | disclosed |