Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.70 |
| ▸ | MAPT | P10636 | 6/20 | 0.70 |
| ▸ | HPGD | P15428 | 3/20 | 0.70 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.70 |
| ▸ | BLM | P54132 | 2/20 | 0.70 |
| ▸ | WRN | Q14191 | 2/20 | 0.70 |
| ▸ | PKM | P14618 | 1/20 | 0.70 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.64 |
| ▸ | NPC1 | O15118 | 5/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.61 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8987358 | 0.88 | ALDH1A1 (0.59) | ALDH1A1MAPTHPGDPTPN7BLM | |
| SCHEMBL5542748 | 0.86 | MAPT (0.54) | ALDH1A1MAPTHPGDPTPN7BLM | |
| SCHEMBL9384667 | 0.84 | KDM4E (0.63) | ALDH1A1MAPTHPGDPTPN7BLM | |
| SCHEMBL5462138 | 0.82 | CDK5 (0.71) | ALDH1A1MAPTHPGDPTPN7BLM | |
| SCHEMBL31611895 | 0.81 | NPC1 (0.63) | ALDH1A1MAPTHPGDPTPN7BLM | |
| SCHEMBL6168341 | 0.80 | DAO (0.57) | ALDH1A1MAPTHPGDPTPN7BLM | |
| SCHEMBL1429201 | 0.78 | NPC1 (1.00) | ALDH1A1MAPTHPGDKDM4ENPC1 | |
| SCHEMBL2008746 | 0.77 | KDR (0.68) | ALDH1A1HPGDKDM4ENPC1RAB9A | |
| SCHEMBL29712353 | 0.77 | KDR (0.68) | ALDH1A1HPGDKDM4ENPC1RAB9A | |
| SCHEMBL9270293 | 0.77 | SMAD3 (0.50) | ALDH1A1MAPTHPGDPTPN7BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6593342-B1 | Activity on the proliferation of clonogenic cells in tumours and comprising an efficient amount of a compound selected among the compounds | LABORATOIRE L. LAFON (FR) | 2003-07-15 | — | — | US | disclosed |
| WO-1995003300-A1 | HETEROARYL QUINOLINES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1995-02-02 | — | — | WO | disclosed |