Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.52 |
| ▸ | KDM5A | P29375 | 2/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.44 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4A | O75164 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30622467 | 0.80 | KDM4C (0.49) | KDM4EKDM4CBRD4 | |
| SCHEMBL1255936 | 0.79 | MAPK14 (0.55) | KDM4EHDAC6KMT2AMEN1BRD4 | |
| SCHEMBL4249708 | 0.79 | KDM4E (0.56) | KDM4EKDM4CHDAC3HDAC4HDAC1 | |
| SCHEMBL27383598 | 0.78 | ALDH1A1 (0.49) | KDM4EALDH1A1KMT2AMEN1PKM | |
| SCHEMBL17457945 | 0.76 | ALDH1A1 (0.53) | KDM4EHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL30497324 | 0.75 | FGFR1 (0.54) | KDM4EKDM4CHDAC1HDAC6KMT2A | |
| SCHEMBL28710506 | 0.74 | KDM4E (0.53) | KDM4EKDM4CHDAC3HDAC4HDAC1 | |
| SCHEMBL14575654 | 0.73 | MAPK8 (0.52) | KDM4EKDM4CKDM5BALDH1A1KDM4A | |
| SCHEMBL31333089 | 0.72 | ADRA1D (0.51) | KDM4EKDM4CHDAC3HDAC4HDAC1 | |
| SCHEMBL21650581 | 0.72 | KMT2A (0.47) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448196-B1 | BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2005-10-12 | — | — | EP | claimed |
| US-6599901-B1 | Adenosine receptor ligands used in the control or prevention of illnesses based on the modulation of the adenosine system, such as Alzheimer's disease | HOFFMAN-LA ROCHE INC. | 2003-07-29 | — | — | US | claimed |
| CN-100346792-C | Benzothiazole derivatives as adenosine receptor ligands | HOFFMANN LA ROCHE (CH) | 2007-11-07 | — | — | CN | disclosed |
| EP-1448196-B1 | BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2005-10-12 | — | — | EP | disclosed |
| CN-1589146-A | Benzothiazole derivatives as adenosine receptor ligands | HOFFMANN LA ROCHE (CH) | 2005-03-02 | — | — | CN | disclosed |
| US-6599901-B1 | Adenosine receptor ligands used in the control or prevention of illnesses based on the modulation of the adenosine system, such as Alzheimer's disease | HOFFMAN-LA ROCHE INC. | 2003-07-29 | — | — | US | disclosed |