Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.45 |
| ▸ | TUBB | P07437 | 4/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.45 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.45 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.45 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.45 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170441 | 0.88 | ALDH1A1 (0.45) | KMT2AMAPTMEN1GAAALDH1A1 | |
| SCHEMBL6169624 | 0.82 | ALOX15 (0.47) | ALDH1A1HPGDELANECYP1A2CYP2C19 | |
| SCHEMBL6168370 | 0.82 | ALDH1A1 (0.46) | KMT2AMAPTMEN1GAAALDH1A1 | |
| SCHEMBL6169500 | 0.79 | MAPT (0.44) | KMT2AMAPTGAAALDH1A1KDM4E | |
| SCHEMBL6171922 | 0.79 | L3MBTL1 (0.41) | KMT2AMAPTMEN1ALDH1A1KDM4E | |
| SCHEMBL27569322 | 0.78 | KMT2A (0.46) | KMT2AMAPTMEN1GAAALDH1A1 | |
| SCHEMBL7203928 | 0.78 | ALDH1A1 (0.52) | KMT2AMAPTMEN1GAAALDH1A1 | |
| SCHEMBL6171751 | 0.77 | ALDH1A1 (0.46) | KMT2AMAPTMEN1GAAALDH1A1 | |
| SCHEMBL6172066 | 0.76 | ALOX15 (0.48) | ALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL6169448 | 0.76 | ALDH1A1 (0.39) | KMT2AMAPTMEN1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |
| EP-1045833-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER INC. (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999035130-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-07-15 | — | — | WO | disclosed |