Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.41 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | STS | P08842 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5836387 | 0.93 | ENPP3 (0.46) | HDAC1HDAC8HDAC6ENPP3ENPP1 | |
| SCHEMBL1003937 | 0.90 | ENPP3 (0.49) | HDAC1HDAC8HDAC6ENPP3ENPP1 | |
| SCHEMBL6168788 | 0.85 | MMP13 (0.42) | HDAC1HDAC8HDAC6ENPP3ENPP1 | |
| SCHEMBL5836945 | 0.81 | ENPP3 (0.54) | HDAC1HDAC8HDAC6ENPP3ENPP1 | |
| SCHEMBL6168787 | 0.79 | MMP13 (0.40) | ENPP3ENPP1PDE4DKDM4EALDH1A1 | |
| SCHEMBL1001041 | 0.78 | SCN10A (0.45) | HDAC1HDAC8HDAC6ENPP3ENPP1 | |
| SCHEMBL1004940 | 0.78 | HDAC1 (0.42) | HDAC1HDAC8HDAC6ENPP3ENPP1 | |
| SCHEMBL3035638 | 0.77 | NPC1 (0.45) | PDE4BKDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL68227 | 0.76 | HDAC1 (0.43) | HDAC1HDAC8HDAC6PDE4BKDM4E | |
| SCHEMBL84528 | 0.76 | ALDH1A1 (0.42) | HDAC1HDAC8HDAC6ENPP3ENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501515-A1 | TRIARYL-OXY-ARYLOXY-PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | Pfizer Products Inc. (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003090752-A1 | TRIARYL-OXY-ARYLOXY-PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2003-11-06 | — | — | WO | disclosed |