Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 4/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168787 | 0.93 | MMP13 (0.40) | MMP13GSK3BENPP3ENPP1PDE4D | |
| SCHEMBL5836387 | 0.92 | ENPP3 (0.46) | ENPP3ENPP1HDAC1HDAC8HDAC6 | |
| SCHEMBL1003937 | 0.88 | ENPP3 (0.49) | ENPP3ENPP1HDAC1HDAC8HDAC6 | |
| SCHEMBL6168616 | 0.85 | HDAC1 (0.41) | ENPP3ENPP1HDAC1HDAC8HDAC6 | |
| SCHEMBL15577165 | 0.77 | PPARG (0.36) | ENPP3ENPP1HDAC1HDAC8HDAC6 | |
| SCHEMBL1001041 | 0.77 | SCN10A (0.45) | GSK3BENPP3ENPP1HDAC1HDAC8 | |
| SCHEMBL1004940 | 0.76 | HDAC1 (0.42) | ENPP3ENPP1HDAC1HDAC8HDAC6 | |
| SCHEMBL3035638 | 0.75 | NPC1 (0.45) | CA2CA9KDM4ENPC1RAB9A | |
| SCHEMBL68227 | 0.75 | HDAC1 (0.43) | HDAC1HDAC8HDAC6KDM4ENPC1 | |
| SCHEMBL3707228 | 0.75 | ALDH1A1 (0.42) | ENPP3ENPP1HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501515-B1 | TRIARYL-OXY-ARYLOXY-PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PROD INC (US) | 2005-11-02 | — | — | EP | disclosed |