Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | GRN | P28799 | 2/20 | 0.44 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13387618 | 0.90 | MAPT (0.47) | ALDH1A1POLBHTTMAPTSMN1; SMN2 | |
| SCHEMBL1576768 | 0.89 | ALDH1A1 (0.53) | ALDH1A1POLBHTTMAPTSMN1; SMN2 | |
| SCHEMBL6169286 | 0.83 | ALDH1A1 (0.50) | ALDH1A1POLBHTTMAPTSMN1; SMN2 | |
| SCHEMBL6407975 | 0.83 | ALDH1A1 (0.43) | ALDH1A1POLBHTTMAPTSMN1; SMN2 | |
| SCHEMBL21245001 | 0.82 | ALDH1A1 (0.64) | ALDH1A1POLBHTTMAPTSMN1; SMN2 | |
| SCHEMBL26104511 | 0.81 | ALDH1A1 (0.50) | ALDH1A1POLBHTTMAPTSMN1; SMN2 | |
| SCHEMBL27878889 | 0.81 | ALDH1A1 (0.50) | ALDH1A1POLBHTTMAPTSMN1; SMN2 | |
| SCHEMBL13387757 | 0.81 | MAPT (0.47) | ALDH1A1POLBHTTMAPTSMN1; SMN2 | |
| SCHEMBL14119926 | 0.81 | MAPT (0.50) | ALDH1A1POLBMAPTSMN1; SMN2CCR2 | |
| SCHEMBL10150650 | 0.81 | MAPT (0.53) | ALDH1A1HTTMAPTSMN1; SMN2CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230416228-A1 | AGENTS FOR THE TREATMENT OF DISEASES BY INHIBITION OF FOXO1 | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEWYORK | 2023-12-28 | — | — | US | disclosed |
| EP-4217355-A1 | AGENTS FOR THE TREATMENT OF DISEASES BY INHIBITION OF FOXO1 | Forkhead Biotherapeutics, inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| WO-2022066938-A1 | AGENTS FOR THE TREATMENT OF DISEASES BY INHIBITION OF FOXO1 | FORKHEAD BIOTHERAPEUTICS, INC. (US) | 2022-03-31 | — | — | WO | disclosed |
| US-20050239808-A1 | Active substances for the treatment, diagnosis and prophylaxis of diseases in which abnormal protein structures occur | TRANSMIT GESELLSCHAFT FUR TECHNOLOGIETRANSFER MBH (DE) | 2005-10-27 | — | — | US | disclosed |
| EP-1503990-A1 | ACTIVE SUBSTANCES FOR THE TREATMENT, DIAGNOSIS AND PROPHYLAXIS OF DISEASES IN WHICH ABNORMAL PROTEIN STRUCTURES OCCUR | Transmit Gesellschaft für Technologietransfer mbH (DE) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003095429-A1 | ACTIVE SUBSTANCES FOR THE TREATMENT, DIAGNOSIS AND PROPHYLAXIS OF DISEASES IN WHICH ABNORMAL PROTEIN STRUCTURES OCCUR | TransMIT Gesellschaft für Technologietransfer mbH (DE) | 2003-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230416228-A1 | AGENTS FOR THE TREATMENT OF DISEASES BY INHIBITION OF FOXO1 | FOXO1, FOXO3, GCKR | ALDH1A1 3526/4885POLB 2588/4885HTT 743/4885 |
| US-20050239808-A1 | Active substances for the treatment, diagnosis and prophylaxis of diseases in which abnormal protein structures occur | PRNP, APP, MAPT | ALDH1A1 1606/4885POLB 3592/4885HTT 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.