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Sugi Predict / Compounds / SCHEMBL6169741

SCHEMBL6169741

SCHEMBL6169741

CC(c1ccncc1-c1ccccc1Cl)C1NC(=O)N(c2ccc(S(=O)(=O)C(F)(F)F)cc2)C1=O

nearest known ligand 0.36

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 2/20 0.36
▸ GPBAR1 Q8TDU6 9/20 0.35
▸ LMNA P02545 1/20 0.35
▸ PTGS2 P35354 5/20 0.33
▸ PTGS1 P23219 1/20 0.32
▸ LIMK1 P53667 1/20 0.30
▸ NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6175297 0.89 LMNA (0.39) IGF1RLMNAPTGS2
SCHEMBL6171408 0.88 IGF1R (0.35) IGF1RLMNAPTGS2
SCHEMBL6171783 0.87 CACNA1B (0.35) IGF1RLMNAPTGS2PTGS1
SCHEMBL6172120 0.86 KDM4E (0.35) IGF1RLMNAPTGS2PTGS1LIMK1
SCHEMBL6173954 0.85 IGF1R (0.36) IGF1RGPBAR1LMNALIMK1
SCHEMBL6175175 0.84 IGF1R (0.36) IGF1RLMNAPTGS2
SCHEMBL6172336 0.84 CACNA1B (0.34) IGF1RLMNAPTGS2PTGS1
SCHEMBL6175007 0.82 SLC22A12 (0.42) IGF1RLMNAPTGS2PTGS1
SCHEMBL6175260 0.82 IGF1R (0.39) IGF1RLMNAPTGS2
SCHEMBL6173330 0.80 IGF1R (0.40) IGF1RLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 — — EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 — — WO disclosed