Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.38 |
| ▸ | GNRHR | P30968 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171474 | 0.89 | PTGS2 (0.58) | PTGS2PTGS1MEN1KMT2A | |
| SCHEMBL6171485 | 0.87 | PTGS2 (0.56) | PTGS2PTGS1MEN1KMT2ATLR8 | |
| SCHEMBL6172077 | 0.87 | PTGS2 (0.71) | PTGS2PTGS1MEN1POLBKMT2A | |
| SCHEMBL6171752 | 0.85 | PTGS2 (0.49) | PTGS2PTGS1MEN1KMT2A | |
| SCHEMBL6169961 | 0.83 | PTGS2 (0.76) | PTGS2PTGS1EGFRMEN1KMT2A | |
| SCHEMBL6174674 | 0.82 | PTGS2 (0.68) | PTGS2PTGS1EGFRMEN1KMT2A | |
| SCHEMBL8113137 | 0.81 | PTGS2 (0.55) | PTGS2PTGS1EGFRMRGPRX4MEN1 | |
| SCHEMBL6174363 | 0.80 | PTGS2 (0.49) | PTGS2PTGS1MEN1KMT2A | |
| SCHEMBL6170156 | 0.80 | PTGS2 (0.50) | PTGS2PTGS1KIF11 | |
| SCHEMBL7207232 | 0.79 | PTGS2 (0.65) | PTGS2PTGS1EGFRMRGPRX4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | claimed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | claimed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |