Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.32 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.30 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171867 | 0.96 | CA2 (0.36) | NR1I2CA1CA2 | |
| SCHEMBL6168308 | 0.81 | CA2 (0.37) | NR1I2CA1CA2 | |
| SCHEMBL6170096 | 0.76 | L3MBTL1 (0.40) | CA1CA2 | |
| SCHEMBL6169180 | 0.76 | KDM4E (0.36) | — | |
| SCHEMBL6178151 | 0.75 | BRS3 (0.36) | CA2CYSLTR2CYSLTR1CNR2 | |
| SCHEMBL6179839 | 0.74 | HRH3 (0.34) | CA1CA2 | |
| SCHEMBL6179821 | 0.74 | ICMT (0.39) | CNR2 | |
| SCHEMBL6181565 | 0.74 | PARP1 (0.38) | CA1CA2 | |
| SCHEMBL6179349 | 0.74 | ICMT (0.34) | CA1CA2CYSLTR2CYSLTR1CNR2 | |
| SCHEMBL6177849 | 0.73 | SCN9A (0.35) | CA2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542999-A1 | 1H-PYRAZOLE AND 1H-PYRROLE-AZABICYCLIC COMPOUNDS WITH ALFA-7 NACHR ACTIVITY | Pharmacia & Upjohn Company LLC (US) | 2005-06-22 | — | — | EP | claimed |
| WO-2004013137-A1 | 1H-PYRAZOLE AND 1H-PYRROLE-AZABICYCLIC COMPOUNDS WITH ALFA-7 NACHR ACTIVITY | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-02-12 | — | — | WO | claimed |