Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.40 |
| ▸ | C5 | P01031 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170675 | 0.91 | MAP2 (0.44) | PTGS2MEN1ABCC4C5MAPT | |
| SCHEMBL6171214 | 0.91 | ALOX15 (0.44) | ENPP2PTGS2MEN1ABCC4C5 | |
| SCHEMBL6168377 | 0.88 | MEN1 (0.46) | PTGS2MEN1ABCC4C5MAPT | |
| SCHEMBL6170363 | 0.87 | ALOX15 (0.43) | PTGS2MEN1ABCC4C5MAPT | |
| SCHEMBL7206121 | 0.87 | ALOX15 (0.48) | ALOX15 | |
| SCHEMBL6171334 | 0.86 | ALOX15 (0.47) | ENPP2PTGS2MEN1ABCC4C5 | |
| SCHEMBL6173340 | 0.86 | PTGS2 (0.40) | ENPP2PTGS2MEN1ABCC4C5 | |
| SCHEMBL6169060 | 0.84 | GPR17 (0.44) | PTGS2MEN1ABCC4C5MAPT | |
| SCHEMBL6171989 | 0.84 | SRD5A2 (0.43) | MAPTKMT2A | |
| SCHEMBL6169317 | 0.82 | ALOX15 (0.44) | PTGS2MEN1ABCC4C5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |