Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2 | P11137 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.43 |
| ▸ | C5 | P01031 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170113 | 0.91 | ENPP2 (0.43) | MAPTPTGS2MEN1ABCC4C5 | |
| SCHEMBL6170210 | 0.91 | MAP2 (0.46) | MAP2MAPTPTGS2MEN1ABCC4 | |
| SCHEMBL7206101 | 0.87 | ALDH1A1 (0.48) | MAPTPTGS2MEN1KMT2AALDH1A1 | |
| SCHEMBL6172849 | 0.85 | ALDH1A1 (0.42) | MAP2MAPTPTGS2MEN1ABCC4 | |
| SCHEMBL6172246 | 0.84 | KMT2A (0.45) | MAPTPTGS2MEN1PTGS1KMT2A | |
| SCHEMBL6171602 | 0.84 | PTGS2 (0.46) | MAP2MAPTPTGS2MEN1ABCC4 | |
| SCHEMBL6171411 | 0.82 | ALOX15 (0.47) | MAP2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6171214 | 0.81 | ALOX15 (0.44) | MAPTPTGS2MEN1ABCC4C5 | |
| SCHEMBL7203961 | 0.80 | ALDH1A1 (0.50) | MAPTPTGS2MEN1KMT2AALDH1A1 | |
| SCHEMBL6170120 | 0.80 | MAPT (0.52) | MAPTPTGS2MEN1PTGS1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |