Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170847 | 0.88 | ESR1 (0.40) | SRD5A2MAPTKMT2AMCL1 | |
| SCHEMBL6171214 | 0.88 | ALOX15 (0.44) | MAPTKMT2A | |
| SCHEMBL7203969 | 0.86 | ALOX15 (0.44) | MCL1 | |
| SCHEMBL6170884 | 0.86 | KIF11 (0.41) | PPARG | |
| SCHEMBL6173340 | 0.86 | PTGS2 (0.40) | MAPTKMT2A | |
| SCHEMBL6168377 | 0.85 | MEN1 (0.46) | MAPTKMT2A | |
| SCHEMBL6171334 | 0.84 | ALOX15 (0.47) | MAPTKMT2A | |
| SCHEMBL6170113 | 0.84 | ENPP2 (0.43) | MAPTKMT2A | |
| SCHEMBL7508028 | 0.82 | CNR1 (0.46) | SRD5A2MAPTCNR1CLK1KMT2A | |
| SCHEMBL6169060 | 0.81 | GPR17 (0.44) | MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-1045833-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER INC. (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999035130-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-07-15 | — | — | WO | disclosed |