Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ESRRA | P11474 | 1/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | WEE1 | P30291 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170913 | 0.94 | KMO (0.48) | KMOEGLN1DYRK1ACMA1MAPT | |
| SCHEMBL7191760 | 0.91 | DYRK1A (0.43) | EGLN1DYRK1AHDAC6ESRRARET | |
| SCHEMBL7813546 | 0.89 | HDAC6 (0.41) | HDAC6 | |
| SCHEMBL6170009 | 0.82 | EGLN1 (0.42) | EGLN1 | |
| SCHEMBL6181826 | 0.82 | RET (0.48) | HDAC6ESRRARETMAPTALDH2 | |
| SCHEMBL7200867 | 0.81 | EGLN1 (0.44) | EGLN1HDAC6MAPT | |
| SCHEMBL6169951 | 0.81 | TSPO (0.46) | EGLN1MAPT | |
| SCHEMBL6170872 | 0.77 | TDP1 (0.46) | DYRK1ASRC | |
| SCHEMBL6168228 | 0.76 | KDM4E (0.46) | MAPT | |
| SCHEMBL6170477 | 0.75 | HASPIN (0.42) | DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097138-B1 | PHARMACEUTICAL COMPOSITIONS COMPRISING 2-QUINOLONES | LAFON LABOR (FR) | 2005-12-07 | — | — | EP | disclosed |
| EP-1097138-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING 2-QUINOLONES | LABORATOIRE L. LAFON (FR) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000003990-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING 2-QUINOLONES | LABORATOIRE L. LAFON (FR) | 2000-01-27 | — | — | WO | disclosed |