Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170477 | 0.93 | HASPIN (0.42) | TDP1HTR2AHTR2CDYRK1AKDM4E | |
| SCHEMBL6170913 | 0.83 | KMO (0.48) | DYRK1AKDM4EALDH1A1HSD17B10RAB9A | |
| SCHEMBL6168228 | 0.83 | KDM4E (0.46) | KDM4EALDH1A1HSD17B10RAB9ANPC1 | |
| SCHEMBL6169951 | 0.81 | TSPO (0.46) | TDP1KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL6170787 | 0.81 | DYRK1A (0.42) | DYRK1AKDM4EALDH1A1HSD17B10RAB9A | |
| SCHEMBL6170009 | 0.81 | EGLN1 (0.42) | — | |
| SCHEMBL6170922 | 0.80 | ALDH1A1 (0.47) | KDM4EALDH1A1HSD17B10RAB9ANPC1 | |
| SCHEMBL6172328 | 0.78 | TSPO (0.54) | TDP1KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL7200867 | 0.78 | EGLN1 (0.44) | ALDH1A1HSD17B10NPC1 | |
| SCHEMBL6169091 | 0.77 | HSP90AA1 (0.37) | KDM4EALDH1A1HSD17B10RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097138-B1 | PHARMACEUTICAL COMPOSITIONS COMPRISING 2-QUINOLONES | LAFON LABOR (FR) | 2005-12-07 | — | — | EP | disclosed |
| US-6593342-B1 | Activity on the proliferation of clonogenic cells in tumours and comprising an efficient amount of a compound selected among the compounds | LABORATOIRE L. LAFON (FR) | 2003-07-15 | — | — | US | disclosed |
| EP-1097138-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING 2-QUINOLONES | LABORATOIRE L. LAFON (FR) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000003990-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING 2-QUINOLONES | LABORATOIRE L. LAFON (FR) | 2000-01-27 | — | — | WO | disclosed |