Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170336 | 0.94 | KMO (0.44) | KMOEGLN1DYRK1AMAPTCMA1 | |
| SCHEMBL6170009 | 0.89 | EGLN1 (0.42) | EGLN1 | |
| SCHEMBL6169951 | 0.86 | TSPO (0.46) | EGLN1RAB9AKDM4EALDH1A1POLB | |
| SCHEMBL7200867 | 0.85 | EGLN1 (0.44) | EGLN1ALDH1A1POLBHSD17B10MAPT | |
| SCHEMBL7191760 | 0.84 | DYRK1A (0.43) | EGLN1DYRK1APOLBMAPT | |
| SCHEMBL6170872 | 0.83 | TDP1 (0.46) | DYRK1ARAB9AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL6168228 | 0.82 | KDM4E (0.46) | RAB9AKDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL7813546 | 0.82 | HDAC6 (0.41) | — | |
| SCHEMBL6170477 | 0.81 | HASPIN (0.42) | DYRK1ARAB9AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL6172328 | 0.80 | TSPO (0.54) | RAB9AKDM4EALDH1A1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097138-B1 | PHARMACEUTICAL COMPOSITIONS COMPRISING 2-QUINOLONES | LAFON LABOR (FR) | 2005-12-07 | — | — | EP | disclosed |
| US-6593342-B1 | Activity on the proliferation of clonogenic cells in tumours and comprising an efficient amount of a compound selected among the compounds | LABORATOIRE L. LAFON (FR) | 2003-07-15 | — | — | US | disclosed |