Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2 | P11137 | 5/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.38 |
| ▸ | C5 | P01031 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171602 | 0.90 | PTGS2 (0.46) | MAP2PTGS2MAPTPTGS1KMT2A | |
| SCHEMBL6171411 | 0.87 | ALOX15 (0.47) | MAP2MAPTKMT2AMEN1KDM4E | |
| SCHEMBL6170687 | 0.85 | MDM2 (0.43) | PTGS2MAPTPTGS1KMT2AMEN1 | |
| SCHEMBL6172849 | 0.85 | ALDH1A1 (0.42) | MAP2PTGS2MAPTPTGS1KMT2A | |
| SCHEMBL7202074 | 0.84 | ALOX15 (0.42) | AKR1C3AKR1C2PTGS2MAPTKMT2A | |
| SCHEMBL6169060 | 0.82 | GPR17 (0.44) | PTGS2MAPTPTGS1KMT2AMEN1 | |
| SCHEMBL6169573 | 0.82 | MEN1 (0.46) | MAP2PTGS2KMT2AMEN1KDM4E | |
| SCHEMBL6170210 | 0.79 | MAP2 (0.46) | MAP2PTGS2MAPTPTGS1KMT2A | |
| SCHEMBL6169876 | 0.79 | PTGS2 (0.46) | PTGS2MAPTPTGS1KMT2AMEN1 | |
| SCHEMBL6168700 | 0.78 | PTGS2 (0.58) | AKR1C3AKR1C2PTGS2PTGS1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |